lizard venom glp-1 The Gila Monster + GLP-1: How a Changed Medicine Gila Monster's Venom: Diabetes Medication

Fluorescent images were acquired with 488 nm and 561 nm excitation for oxidized and reduced forms of dye respectively 19

The study suggests that combining RT with whey protein may improve sarcopenia outcomes and preserve muscle function after training stops

and Virginie Badon of the Centre dInvestigation Clinique CIC 1413, INSERM, CHU de Nantes

Mechanism of Action Blocks L-type calcium channels in vascular smooth muscle Causes arterial vasodilation Peripheral vascular resistance blood pressure Minimal effect on heart rate (unlike non-dihydropyridines) Indications Hypertension Chronic stable angina Variant (Prinzmetal) angina Sometimes used in Raynauds phenomenon or coronary artery disease adjunct therapy Dosage (Adults) Hypertension: 510 mg orally once daily Angina: 510 mg orally once daily Start low, titrate based on response Advantages Once-daily dosing (long half-life ~3050 hours) Good tolerability Safe in elderly and in combination with other antihypertensives Side Effects Peripheral edema (most common) Dizziness Flushing Headache Palpitations (rare) Fatigue Contraindications / Cautions Severe hypotension Cardiogenic shock Significant aortic stenosis (use cautiously) Hepatic impairment (dose adjustment may be needed) Dihydropyridines mainly vascular effects (edema, flushing)